- A new and highly effective organometallic approach to 1,2-dehalogenations and related reactions
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We investigated the reductive elimination of several functionalized and non-functionalized vic-dibromides with 1,2-diphenyl-, 1,1,2,2-tetraphenyl- and 1-phenyl-2-(2-pyridyl)-1,2-disodioethane. The reaction, involving some of the less expensive organic and inorganic reagents, proceeds under mild conditions, and is tolerant of a variety of functional groups. Extension of this procedure to similar 1,2-disubstituted compounds was also investigated. Reductive eliminations run on stereochemical probe compounds strongly suggest that this reaction proceeds via a "single electron" reductive elimination reaction pathway.
- Azzena, Ugo,Pittalis, Mario,Dettori, Giovanna,Pisano, Luisa,Azara, Emanuela
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p. 3892 - 3900
(2008/03/12)
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