Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis
We have prepared a novel speculative eight-membered lactam demonstration library based on the skeletal structure of the potent antitumor marine natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via ring-closing metathesis chemistry from the corresponding diene amides. A cursory examination of the biological properties of the library validates the relevance and significance of these structures.
Brown, Neil,Xie, Baohan,Markina, Nataliya,VanderVelde, David,Perchellet, Jean-Pierre H.,Perchellet, Elisabeth M.,Crow, Kyle R.,Buszek, Keith R.
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p. 4876 - 4879
(2009/05/30)
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