- MODULATORS FOR AMYLOID BETA
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The invention relates to compounds of formula (I) wherein R1 is hydrogen, lower alkyl or is lower alkyl substituted by hydroxy; R2 is hydrogen, lower alkoxy or lower alkyl; R3 /R4 are independently from each other hydrogen, halogen, lower alkyl, C(O)O-low
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Page/Page column 30
(2010/04/28)
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- NOVEL SUBSTITUTED BENZOXAZOLE, BENZIMIDAZOLE, OXAZOLOPYRIDINE AND IMIDAZOPYRIDINE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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Page/Page column 95
(2010/09/17)
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- MODULATORS OF AMYLOID BETA
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The invention relates to compounds of formula wherein hetaryl I, hetaryl II, and R1 are as described herein. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease.
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Page/Page column 22
(2011/07/06)
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