Synthetic studies on statins. Part 1: A short and cyanide-free synthesis of atorvastatin calcium via an enantioselective aldol strategy
A short and cyanide-free enantioselective synthesis of atorvastatin calcium has been achieved starting from a commercially available highly substituted 1,4-diketone in an overall yield of 40%. The key step in this approach is the asymmetric aldol reaction of an aldehyde with diketene in the presence of Ti(O-i-Pr)4-Schiff base complex to create the (5R)-stereochemistry of atorvastatin calcium.
3-Nitropropanal, 3-Nitropropanol, and 3-Nitropropanal dimethyl acetal [ Propanal, 3-nitro-; 1-Propanol, 3-nitro-; and Propane, 1,1-dimethoxy-3-nitro-]
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Griesser,?hrlein,Schwab,Ehrler,J?ger,Davidson, James P.,Martin, Stephen F.
p. 236 - 236
(2017/10/06)
3-Nitropropanal and 3-Nitropropanol: Preparation of the Parent Compounds and Derivatives
3-Nitropropanal has been prepared for the first time by 1,4-nitrite addition to acrolein.Several acetals of 3-nitropropanal are described, as well as 3-nitropropanol and some of its ethers. 3-Nitropropanol has been obtained by borane-dimethyl sulfide reduction of both 3-nitropropanal and 3-nitropropanoic acid.These reactions make available a variety of nitro compounds known as, or expected to become, highly useful and versatile building blocks for organic syntheses.