- A Facile Synthesis of 3-(Arylthio)imidazo[1,2-a]pyridin-2(3H)-ones from 2-Aminopyridinium Bromides and Sodium Arenesulfinates
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A simple and convenient method has been developed for the synthesis of 3-(arylthio)imidazo[1,2-a]pyridin-2(3H)-ones through a catalyst-free reaction of 2-aminopyridinium bromides with sodium arenesulfinates. A variety of 3-(arylthio)imidazo[1,2-a]pyridin-2(3H)-ones were obtained in moderate to excellent (33–85 %) yields. The developed protocol is operationally simple, exhibits a broad substrate scope with a wide range of functional groups, and is amenable for gram-scale synthesis.
- Kumar, Anil,Rangan, Krishnan,Saroj
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- Metal-free synthesis of pyridin-2-yl ureas from 2-aminopyridinium salts
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An unprecedented base promoted domino approach has been developed for the synthesis of pyridin-2-yl urea derivatives via the reaction of 2-aminopyridinium salts and arylamines. The developed strategy tolerated a wide range of functional groups and afforded pyridin-2-yl ureas in moderate to good yields. The reaction was postulated to involve tandem cyclization, intermolecular nucleophilic addition, ring opening, and demethylation.
- Saroj,Patel, Om P.S.,Rangan, Krishnan,Kumar, Anil
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- An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence
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An efficient method to prepare 2,3-diarylimidazo[1,2-a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2-a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of highly functionalized 2,3-diarylimidazo[1,2-a]pyridines.
- Marhadour, Sophie,Bazin, Marc-Antoine,Marchand, Pascal
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experimental part
p. 297 - 300
(2012/01/31)
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- CHYMASE INHIBITORS
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Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
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Page/Page column 26
(2008/06/13)
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