4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF
The present invention provides an antitumor agent comprising a compound or a pharmaceutically acceptable salt thereof that covalently binds to GTP-bound KRASG12C as an active ingredient.
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Paragraph 0412
(2021/05/07)
PHARMACEUTICAL COMPOUNDS
The invention provides new pyrazine derivatives of formula (I), or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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Page/Page column 161
(2019/09/18)
ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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Page/Page column 56-57
(2012/04/04)
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