- Synthesis and properties of 2',5'-adenylate trimers bearing 2'-terminal 8-bromo or 8-hydroxyadenosine
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Trimers of 2',5'-oligoadenylic acids bearing 2'-terminal 8-bromo- or 8-hydroxyadenosine have been synthesized by the phosphotriester method.Some properties of these compounds were studied by circular dichroism (CD) spectroscopy.The 2',5'-adenylate trimer, A2'p5'A2'p5'HOA (10a) was found to have less stacked structure than the 2',5'-adenylate trimers A2'p5'A2'p5'BrA (11) and A2'p5'A2'p5'A (10b).Keywords - modified 2',5'-adenylate trimer; N6,N6,3'-O-tribenzoyladenosine; 8-bromoadenosine; coupling agent; CD spectrum; HPLC; reversed-phase liquid chromatography.
- Yoshida, Shiro,Takaku, Hiroshi
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p. 2456 - 2461
(2007/10/02)
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