Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.
Hanan, Emily J.,Fucini, Raymond V.,Romanowski, Michael J.,Elling, Robert A.,Lew, Willard,Purkey, Hans E.,VanderPorten, Erica C.,Yang, Wenjin
scheme or table
p. 5186 - 5189
(2009/05/07)
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