Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs
(Chemical Equation Presented) Although 02-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished antiproliferative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation.
Chakrapani, Harinath,Maciag, Anna E.,Citro, Michael L.,Keefer, Larry K.,Saavedra, Joseph E.
supporting information; experimental part
p. 5155 - 5158
(2009/06/06)
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