Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution
New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d
Jou, Gemma,Gonzalez, Isabel,Albericio, Fernando,Lloyd-Williams, Paul,Giralt, Ernest
p. 354 - 366
(2007/10/03)
EFFECT OF THE NATURE OF THE ALKYL RADICAL ON THE BIOLOGICAL ACTIVITYOF N-CARBOXYALKYL DIPEPTIDES
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Krit, N. A.,Gracheva, I. N.,Filatova, M. P.,Reissmann, S.
p. 482 - 485
(2007/10/02)
Amino Acid Esters as Chiral Auxiliaries in Barbier-Type Reactions in Aqueous Solution
Valine and proline benzyl ester are converted into the aliphatic and aromatic α-oxo amides 5 by activation of the respective α-oxo acid by means of N,N'-diisopropylcarbodiimide.The α-oxo amides 5 undergo Barbier-type reactions with differently substituted
Waldmann, Herbert
p. 1317 - 1322
(2007/10/02)
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