Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase
Bacillus anthracis, the causative agent of anthrax, poses a significant biodefense danger. Serious limitations in approved therapeutics and the generation of resistance have produced a compelling need for new therapeutic agents against this organism. Baci
Beierlein, Jennifer M.,Frey, Kathleen M.,Bolstad, David B.,Pelphrey, Phillip M.,Joska, Tammy M.,Smith, Adrienne E.,Priestley, Nigel D.,Wright, Dennis L.,Anderson, Amy C.