Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for σ1 receptor ligands based on a series of substituted benzo[d ]oxazol-2(3H)-one derivatives
Novel benzo[d ]oxazol-2(3H)-one derivatives were designed and synthesized, and their affinities against σ receptors were evaluated. On the basis of 31 compounds, a three-dimensional pharmacophore model for the σ1 receptor binding site was devel
Zampieri, Daniele,Mamolo, Maria Grazia,Laurini, Erik,Florio, Chiara,Zanette, Caterina,Fermeglia, Maurizio,Posocco, Paola,Paneni, Maria Silvia,Pricl, Sabrina,Vio, Luciano
experimental part
p. 5380 - 5393
(2010/02/28)
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