The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 00239
(2018/06/30)
Synthesis of (-)-Cytisine Using a 6- endo aza-Michael Addition
An asymmetric synthesis of (-)-cytisine has been achieved. The piperidine C-ring was formed using a stereodivergent intramolecular 6-endo aza-Michael addition. The B-ring was established by intramolecular pyridine N-alkylation. The absolute stereochemistry was established by an Evans acyl oxazolidinone enolate alkylation reaction that proceeded with an unexpected stereochemical outcome due to participation of the pyridine nitrogen lone pair.
Barát, Viktor,Csókás, Dániel,Bates, Roderick W.
p. 9088 - 9095
(2018/07/25)
COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I'" or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
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Paragraph 0784
(2017/03/14)
Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
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Page/Page column 25
(2012/07/28)
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