Solid-phase synthesis of unnatural amino acids using unactivated alkyl halides
Conditions were developed for the efficient alkylation of the resin-bound benzophenone imine of glycine with a variety of unreactive alkyl halides. Alkylations were accomplished at room temperature in NMP using the phosphazene-type base, BEMP.
O'Donnell, Martin J.,Lugar, Charles W.,Pottorf, Richard S.,Zhou, Changyou,Scott, William L.,Cwi, Cynthia L.