PEt3-mediated deoxygenative C–N coupling of nitroarenes and boronic acids
A method for the preparation of aryl- and heteroarylamine products by triethylphosphine-mediated deoxygenative coupling of nitroarenes and boronic acids is reported. This method provides access to an array of functionalized (hetero)arylamine products from readily available starting materials under the action of an inexpensive commercial reagent. The developed triethylphosphine-mediated transformation highlights the capability of organophosphorus compounds to carry out this useful deoxygenative transformation without the necessity of any transition metal additives.
Nykaza, Trevor V.,Yang, Junyu,Radosevich, Alexander T.
supporting information
p. 3248 - 3252
(2019/04/25)
IMPROVED PROCEDURE FOR THE REDUCTIVE PHENYLATION AND CYCLIZATION OF NITROARENES
The reductive phenylation of nitroarenes was improved by using iron pentacarbonyl(IPC) as a reducing reagent.The method was applied to the synthesis of ellipticine and dibenzazocine derivatives.