- Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide
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A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.
- Cheng, Xiu-Fen,Wang, Tao,Li, Yan,Wu, Yun,Sheng, Jie,Wang, Rui,Li, Chao,Bian, Kang-Jie,Wang, Xi-Sheng
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supporting information
p. 6530 - 6533
(2018/10/20)
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- Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acids
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(Chemical Equation Presented) Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acid substrates has been achieved through the use of monoprotected chiral amino acid ligands. The absolute configuration of the resulting olefinated products
- Shi, Bing-Feng,Zhang, Yang-Hui,Lam, Jonathan K.,Wang, Dong-Hui,Yu, Jin-Quan
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supporting information; experimental part
p. 460 - 461
(2010/03/25)
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