Improved Synthesis of 6β,7β-Epoxy-17β-hydroxy-3-oxo-4,6-pregnadiene-21-carboxylic Acid γ-Lactone
The title compound 2, a metabolite of canrenone (1) in rats, is synthesized starting from 1 via derivative 3c in a 25-g scale in a much shorter time and higher yield than in the literature cited.
Reinholz, Erhard,Vogler, Fritz
p. 1015 - 1016
(2007/10/02)
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