cas 110104-37-5, N2-ACETYL-9-[(2'-HYDROXYETHOXY)METHYL]GUANINE | Articles data ｜lookchem

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110104-37-5

Articles about 110104-37-5Total 7 be found

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Regioselective synthesis of acyclovir and its various prodrugs
High-yield regioselective synthesis of 9-[(2-hydroxyethoxy)methyl]guanine (Acyclovir 1, Scheme 1) was achieved from guanine via trisilylated guanine. N2-acylacyclovir 9a-9b were prepared from N2, O-diacylacyclovir (4, 8b-8d) using regioselective deacylation procedure. N2-Acylacyclovir 11 and 13 were prepared via protection of primary hydroxyl groups. Three amino acid esters of acyclovir were synthesized as water-soluble prodrugs, which form protonated cations in pH 7.4 phosphate buffer. Two water-soluble ester prodrugs with free carboxylic acids, which form anionic species in pH 7.4 phosphate buffer, were also synthesized.
Gao,Mitra
p. 1399 - 1419
(2007/10/03)

A novel palladium-catalyzed deoxygenation of guanine O6-arenesulfonates. A practicable synthesis of 2-aminopurine nucleosides and related analogs
A simple synthesis of 2-aminopurine nucleosides and related derivatives has been accomplished from the corresponding guanine O6-arenesulfonates. Studies towards the determination of optimum conditions for reduction and regioselectivity control are also reported.
Stimac,Muhic,Kobe
p. 625 - 636
(2007/10/02)

9-substituted guanines
Novel compounds, 9-substituted guanines, with the following general formula STR1 where R' is acetyl; R" is 2-tetrahydrofuryl or 2-tetrahydropyranyl. The proposed compounds have antiviral activity.
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(2008/06/13)

A new synthesis of acyclovir prodrugs. N2-acetylacyclovir and 6-deoxyacyclovir
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Stimac,Kobe
p. 461 - 464
(2007/10/02)

Process for preparing purine derivates
There is disclosed a process for preparing purine derivatives of the formula I wherein, R1 represents hydrogen, CH3CO or a higher acyl,R3 represents hydrogen, CH3CO or a higher acyl, CF3CO, CCl3CO, PhCO or CH2 AR, such as benzyl or substituted benzyl, and benzoisothiazolyl-S,S-dioxide, and, Z represents OH, hydrogen or halo. Said compounds are either drugs or prodrugs for the treatment of herpes infections. There are also disclosed some novel compounds of formula I useful as prodrugs.
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(2008/06/13)

A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) and related compounds
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Matsumoto,Kaneko,Yamada,Takeuchi,Mori,Mizuno
p. 1153 - 1157
(2007/10/02)

Synthesis and anti-herpes-virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
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Martin,McGee,Jeffrey,Hobbs,Smee,Matthews,Verheyden
p. 1384 - 1389
(2007/10/02)

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Chemical Properties

Melting Point: 217℃
Density: 1.63 g/cm³
Solubility:DMSO (Slightly. Heated), Methanol (Slightly, Heated, Sonicated), Water (Very Sli
Storage Temp.:Refrigerator
PKA: pKa 8.54±0.03(H2O t=RT I=0.25 ) (Uncertain)
PSA: 122.13000
LogP: -0.88260

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