Diastereoselective synthesis of a spironoraristeromycin using an acylnitroso Diels-Alder reaction
(Chemical Equation Presented) The tert-butyl N-hydroxycarbamate-derived nitroso reagent 1 reacted with N-Cbz-protected spirocyclic diene 2 to provide spirocycloadduct 3. Here we describe the efficient conversion of 3 into the novel carbocyclic nucleoside
Lin, Weimin,Virga, Kristopher G.,Kim, Kyung-Hee,Zajicek, Jaroslav,Mendel, David,Miller, Marvin J.
Syntheses of new spirocarbocyclic nucleoside analogs using iminonitroso diels-alder reactions
(Chemical Equation Presented) N-Cbz- and Boc-protected spirocyclic dienes were prepared by dialkylation of cyclopentadiene. These dienes coupled efficiently in a series of iminonitroso Diels-Alder reactions to produce a series of new spirocyclic adducts.
Lin, Weimin,Gupta, Anuradha,Kim, Kyung Hee,Mendel, David,Miller, Marvin J.