- Synthesis of acyclic nucleoside phosphonates as antiviral compounds
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Reaction of 6-chloropyrimidines with diethyl [(2-aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5-substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV-1 and HSV-2) and human immunodeficiency virus (HIV-1). Some compounds showed weak antiviral activity against HSV-1.
- Wormstadt,Brinckmann,Gutschow,Eger
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- Insertion polymerization of divinyl formal
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Copolymerization of ethylene and divinyl formal by [{κ2-P,O-(2-MeOC6H4)2PC6H4SO3}PdMe(dmso)] (1) by a coordination-insertion mechanism affords highly linear polyethylenes with a high (12.5 mol %) incorporation of divinyl formal. This significantly exceeds the thus far relatively low incorporation (6.9 mol %) and activity with vinyl ether monomer in insertion polymerization. The resulting ethylene-divinyl formal copolymers exclusively (>98%) contain five-membered (trans-1,3-dioxolane) and six-membered (cis-/trans-1,3-dioxane) cyclic acetal units in the main chain, and also in the initiating ends of this functionalized polyethylene. Comprehensive NMR analysis of the microstructure of these copolymers revealed that under pressure reactor conditions consecutive 2,1-1,2-insertion of divinyl formal into a Pd-H bond is preferred, but consecutive 1,2-1,2-insertion of divinyl formal into more bulky Pd-alkyls (growing polymer chain) is favored. Moreover, homopolymerization of divinyl formal yielded a non-cross-linking poly(divinyl formal) with degrees of polymerization of DPn ≈ 26.
- Jian, Zhongbao,Mecking, Stefan
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p. 4395 - 4403
(2016/07/07)
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- Synthesis of Di(2-chloroethyl) Formal
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Methods for preparing di(2-chloroethyl) formal and compositions of reaction mixtures obtained by various methods are described.
- Gubaidullin. L. Yu.,Chugunov, Yu. V.,Ioffe, D. S.,Gubaidullin, I. L.,Tyut'ko, K. A.,et al.
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p. 153 - 154
(2007/10/03)
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- Liquid-phase fluorination
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This invention pertains to a method for liquid phase fluorination for perfluorination of a wide variety of hydrogen-containing compounds.
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- Liquid phase fluorination
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This invention pertains to a method for liquid phase fluorination for perfluorination of a wide variety of hydrogen-containing compounds.
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