Method of preparing aryl-(1-phthalimido)-alkyl ketones
Aryl-(1-phthalimido)-alkyl ketones of the general formula STR1 are prepared by reacting a suitable aromatic compound with STR2 at least one hydrogen atom on the aromatic nucleus in an inert solvent and in the presence of iron-(III)-chloride with an N-phth
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(2008/06/13)
Ferric Chloride-Catalyzed Acylation of Aromatic Compounds with N-Phthaloyl-α-amino Acyl Chlorides without Racemisation
Reactive aromatic compounds are acylated without racemisation to aryl 1-phthalimidoalkyl ketones 4 in good yields with N-phthaloyl-α-amino acid chlorides in the presence of catalytic amounts (1 to 5 mol-percent) of FeCl3.This new method is especially useful for the synthesis of the pharmacologically interesting alkoxyaryl 1-phthalimidoalkyl ketones 6, 8, 10, and 11, which cannot be prepared in reasonable yields in the presence of other FC catalysts such as AlCl3 or SnCl4.
Effenberger, Franz,Steegmueller, Dieter
p. 117 - 124
(2007/10/02)
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