Promotion of mitochondrial biogenesis by synthetic 1,2- or 1,3-digallates through activation of an energy sensing network
Based on the observations suggesting that a digallate functionality might serve as a novel scaffold for inducers of mitochondrial biogenesis, we prepared a series of digallates and evaluated their activity in an in vitro model widely used in PD research (
Chong, Youhoon,Kim, Mi Kyoung,Lee, Taegum
supporting information
(2022/01/08)
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
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Page/Page column 64; 65
(2015/09/22)
New synthetic inhibitors of fatty acid synthase with anticancer activity
Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers. Here we report the development of a new series of polyphenolic compounds 5-30 that have been evaluated for their cytotoxic capacity in SK-Br3 cells, a hu
Turrado, Carlos,Puig, Teresa,García-Cárceles, Javier,Artola, Marta,Benhamú, Bellinda,Ortega-Gutiérrez, Silvia,Relat, Joana,Oliveras, Gloria,Blancafort, Adriana,Haro, Diego,Marrero, Pedro F.,Colomer, Ramón,López-Rodríguez, María L.
experimental part
p. 5013 - 5023
(2012/07/30)
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