- Molecular structure and intramolecular hydrogen bond strength of 3-methyl-4-amino-3-penten-2-one and its N–Me and N-Ph substitutions by experimental and theoretical methods
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In the present work, molecular structures and intramolecular hydrogen bonding (IHB) of 3-methyl-4-amino-3-penten-2-one, 3-MeAPO, 3-methyl-4-methylamino-3-penten-2-one, 3-Me-MeAPO, and the 3-methyl-4-phenylamino-3-penten-2-one, 3-Me-PhAPO have been investi
- Seyedkatouli, Seyedabdollah,Vakili, Mohammad,Tayyari, Sayyed Faramarz,Hansen, Poul Erik,Kamounah, Fadhil S.
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- 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES
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The present invention provides, in part, compounds of Formula (I): or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N- oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.
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Page/Page column 73; 74
(2018/02/03)
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- Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies
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The first photocycloadditions of aromatic and aliphatic aldehydes to methylated isoxazoles are reported. The reactions lead solely to the exo-adducts with high regio- and diastereoselectivities. Ring methylation of the isoxazole substrates is crucial for high conversions and product stability. The 6-arylated bicyclic oxetanes 9a-9c were characterized by X-ray structure analyses and showed the highest thermal stabilities. All oxetanes formed from isoxazoles were highly acid-sensitive and also thermally unstable. Cleavage to the original substrates is dominant and the isoxazole derived oxetanes show type T photochromism.
- Griesbeck, Axel G.,Franke, Marco,Neudoerfl, Joerg,Kotaka, Hidehiro
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p. 127 - 134
(2011/05/16)
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- KINETICS OF CYCLIZATION OF 1-PHENYL-3-(1,2-DIMETHYL-3-OXO-1-BUTENYL)UREA AND ETHYL 2-METHYL-3-N-(N'-PHENYLUREIDO)-2-BUTENOATE
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1-Phenyl-3-(1,2-dimethyl-3-oxo-1-butenyl)urea (III) has been prepared by reaction of phenyl isocyanate with 4-amino-3-methyl-3-penten-2-one (I).Ethyl 2-methyl-3-N-(N'-phenylureido)-2-butenoate (V) has been prepared by analogous reaction with ethyl 3-amino
- Kavalek, Jaromir,Hruska, Jiri,Sterba, Vojeslav
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p. 518 - 522
(2007/10/02)
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