- Preparation method of 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate
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The invention provides a preparation method of 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate, and the method comprises the following steps: S1, adding N-(2-aminoethyl) morpholine into a first organic solvent, and dropwise adding cyclohexyl isocyanate to generate an intermediate 1; S2, carrying out intramolecular dehydration reaction on the intermediate 1 to obtain an intermediate 2; S3, enabling the intermediate 2 to react with methyl p-toluenesulfonate, so as to generate the 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate. According to the preparation method of the 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate disclosed by the embodiment of the invention, a product with high purity can be smoothly obtained, and the method is good in operability, higher and stable in yield and easily available in raw materials.
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Paragraph 0033; 0058-0060; 0066-0068
(2021/05/08)
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- Synthesis of hydantocidin and C-2-thioxo-hydantocidin
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Hydantocidin, a naturally occurring strong herbicide, was synthesized in an overall yield of 35.2%, with the accompanying 1′-epi-hydantocidin in overall 9.6% yield from 2,3-O-isopropylidene-D-ribono-1,4-lactone. C-2-thioxo-hydantocidin and its spiro-epimer were also synthesized in an overall yield of 14.4% and 8.5%, respectively.
- Shiozaki, Masao
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p. 147 - 150
(2007/10/03)
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