- Synthesis and Bioevaluation of Macrocycle-Polyamine Conjugates as Cell Migration Inhibitors
-
The motuporamines are natural products isolated from the New Guinea sea sponge Xestospongia exigua. Dihydromotuporamine C contains a large macrocycle and an appended polyamine component and was shown to be both antimetastatic and cytotoxic to human L3.6pl pancreatic cancer cells. A series of macrocycle-polyamine conjugates were prepared, and the sequence of the polyamine component was varied to optimize the antimigration properties (as measured in L3.6pl cells) of this molecular class. A one-carbon spacer between the 15-membered carbocycle and the appended polyamine showed improved antimigration properties. A survey of different polyamine sequences containing two, three, or four carbon spacers revealed that the natural polyamine sequence (norspermidine, a 3,3-triamine) was superior in terms of inhibiting the migration of L3.6pl cells in vitro. An investigation of the respective ceramide and sphingomyelin populations in L3.6pl cells revealed that these molecules can modulate both ceramide and sphingomyelin pools in cells and inhibit cell migration.
- Skruber, Kristen,Chaplin, Kelvin J.,Phanstiel, Otto
-
-
Read Online
- 6-Polyamino-substituted quinolines: Synthesis and multiple metal (CuII, HgII and ZnII) monitoring in aqueous media
-
Chemoselective palladium-catalyzed arylation of polyamines with 6-bromoquinoline has been explored to prepare chelators for the detection of metal cations in aqueous media. The introduction of a single aromatic moiety into non-protected polyamine molecules was achieved using the commercially available Pd(dba)2/BINAP precatalyst to afford nitrogen chelators, in which the aromatic signalling unit is directly attached to the polyamine residue. Water-soluble receptors were then synthesized using N-alkylation of these polyamines by hydrophilic coordinating residues. By combining rich photophysical properties of the 6-aminoquinoline unit with a high coordination affinity of chelating polyamines and a hydrophilic character of carboxamido-substituted phosphonic acid diesters in a single molecular device, we synthesized chemosensor 5 for selective double-channel (UV-vis and fluorescence spectroscopies) detection of CuII ions in aqueous media at physiological levels. This receptor is suitable for the analysis of drinking water and fabrication of paper test strips for the naked-eye detection of CuII ions under UV-light. By increasing the number of donor sites we also obtained chemosensor 6 which is efficient for the detection of HgII ions. Moreover, chemosensor 6 is also suitable for multiple detection of metal ions because it chelates not only HgII but also CuII and ZnII ions displaying different responses of emission in the presence of these three cations.
- Abel, Anton S.,Averin, Alexei D.,Cheprakov, Andrey V.,Roznyatovsky, Vitaly A.,Denat, Franck,Bessmertnykh-Lemeune, Alla,Beletskaya, Irina P.
-
-
Read Online
- Propanil emulsifiable concentrate herbicide and preparation method thereof
-
The invention discloses a propanil emulsifiable concentrate herbicide, belongs to the technical field of herbicides, and comprises the following raw materials in percentage by weight: 1 - 35% parts of propanil. Ether 1 - 20%, isophorone 1 - 20%, crowndaisy chrysanthemum extract 4 - 15%, potassium nitrate 2 - 10%, emulsifier 3 - 5%, dispersant 1 - 3%, defoaming agent 1 - 3%, ultraviolet absorber 3 - 6%, vegetable oil 10 - 20% and the balance are carrier. The invention further discloses a preparation method of the herbicide. In the herbicide formula, the ultraviolet absorbent is added in the herbicide formula, so that the compound herbicide has the effects of oxidation resistance, aging resistance, ultraviolet aging resistance, effective component visible light decomposition, and persistent drug effect.
- -
-
Paragraph 0040; 0068; 0076; 0078; 0086; 0088; 0096
(2021/10/27)
-
- PROCESS FOR PREPARING CYCLIC ALKYLENE UREAS
-
A process for producing a cyclic alkylene urea product of Formula I: in which a compound of Formula II and/or Formula III is contacted in a reaction zone with a compound of Formula IV and/or Formula V and in the presence of one or more carbonyl delivering compounds; in which; R1 is –[A?X?]qR3; R2 is on each occurrence independently selected from H and C1 to C6 alkyl groups which are optionally substituted by one or two groups selected from ?OH and ?NH2; R3 is on each occurrence independently selected from H and C1 to C6 alkyl groups which are optionally substituted by one or two groups selected from ?OH and ?NH2; A is on each occurrence independently selected from C1 to C3 alkylene units, optionally substituted by one or more C1 to C3 alkyl groups; X is on each occurrence independently selected from ?O?, ?NR2?, groups of Formula VI, and groups of Formula VII and p and q are each independently selected from a whole number in the range of from 0 to 8; wherein the compound of Formula II and/or the compound of Formula III are added to a reaction zone comprising compound of Formula IV and/or compound of Formula (V) continuously or semi-continuously over a period of time, or in two or more batches.
- -
-
Page/Page column 14-15
(2019/02/25)
-
- PROCESS TO CONVERT THE CYCLIC MONOUREA OF AN ETHYLENE AMINE COMPOUND INTO THE ETHYLENE AMINE COMPOUND
-
The present invention relates to a process to convert the cyclic monourea of ethylene amine compounds (U-EA) into ethylene amine compound (EA) by performing a reactive separation step using a reaction mixture containing the cyclic monourea, wherein one cyclic monourea (U-EA) reacts with another cyclic monourea (U-EA) to transfer its urea unit thereto and the obtained ethylene amine compound (EA) without urea unit is separated from the reaction mixture.
- -
-
Page/Page column 9-10
(2019/02/25)
-
- TWO-STEP PROCESS FOR CONVERTING CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES
-
The invention pertains to a process for converting cyclic alkyleneureas into their corresponding alkyleneamines, comprising - in a first step converting cyclic alkyleneureas into their corresponding alkyleneamines by reacting cyclic alkyleneureas in the liquid phase with water with removal of CO2, so as to convert between 5 mole% and 95 mole% of alkyleneurea moieties in the feedstock to the corresponding amines, and - in a second step adding an inorganic base and reacting cyclic alkylene ureas remaining from the first step with the inorganic base to convert them partially or completely into their corresponding alkyleneamines. It has been found that the two-step process of the present invention makes it possible to still obtain a high conversion of cyclic alkyleneureas, while using substantially less strong inorganic base. The process according to the invention also shows a higher selectivity to amines than the prior art process.
- -
-
Page/Page column 22-24
(2019/02/25)
-
- PROCESS FOR CONVERTING CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES
-
The invention relates to a process for converting one or more cyclic ethylene ureas into corresponding ethylene amines and carbon dioxide. In the process, water is contacted with one or more cyclic alkylene urea compounds comprising one or more cyclic alkylene urea moieties in a reaction vessel at a temperature of 150 to 400°C, optionally in the presence of an amine compound selected from the group of primary amines, cyclic secondary amines and bicyclic tertiary amines. The mole ratio of water to cyclic alkylene urea moieties is in the range of from 0.1 to 20. In the reaction, at least a portion of the cyclic alkylene urea moieties are converted to corresponding alkylenediamine moieties and carbon dioxide, and the carbon dioxide is removed from the liquid reaction mixture in a stripping vessel by feeding a stripping fluid to the stripping vessel, and removing a carbon dioxide-containing stripping fluid.
- -
-
Page/Page column 20-21; 17-18
(2019/02/25)
-
- PROCESS FOR CONVERTING CYCLIC ALKYLENEUREAS INTO THEIR CORRESPONDING ALKYLENEAMINES
-
The present invention is directed to a process for converting cyclic alkyleneureas into their corresponding alkyleneamines wherein a feedstock comprising cyclic alkyleneureas is reacted in the liquid phase with water in an amount of 0. -20 mole water per mole urea moiety, at a temperature of at least 230°C, with removal of CO2. It has been found that the process according to the invention allows the efficient conversion of alkyleneureas into the corresponding alkyleneamines. The process has a high yield and low side product production. It is preferred for the cyclic alkyleneurea to comprises one or more of EU (ethyleneurea, the urea derivative of ethylenediamine (EDA)), UDETA (the urea derivative of diethylenetriamine (DETA)), UTETA (the group of urea derivatives of triethylenetetraamine (TETA), DUTETA (the diurea derivative of triethylenetetramine), UTEPAs (the urea derivatives of tetraethylenpentamine (TEPA)), DUTEPAs (the diurea derivatives of TEPA), or urea derivatives of pentaethylenehexamine (PEHA) and higher analogues, UAEEA (the urea derivative of aminoethylethanolannine), HE-UDETA (the urea derivative of hydroxyethyl diethylenetriamine), HE-UTETA (the urea derivative of hydroxyethyl triethylenetetraamine, HE-DUTETA (the diurea derivative of hydroxyethyl triethylenetetraamine), or any mixture of these.
- -
-
Page/Page column 13; 14; 15
(2019/02/25)
-
- METHOD FOR PRODUCING POLYETHYLENE POLYAMINES
-
PROBLEM TO BE SOLVED: To provide a method for producing polyethylene polyamines with high selectivity and high yield. SOLUTION: In the presence of a solid acid catalyst, ethylene amines and aziridine are reacted with each other so that an equivalent of ethylene amines is 3 equivalents or more and 30 equivalents or less relative to aziridine. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
- -
-
Paragraph 0051-0052
(2018/02/27)
-
- IMPROVED METHOD FOR THE SYNTHESIS OF 1,2-ETHANEDIAMINE, N, N'-BIS(2-AMINOETHYL)-DIHYDROCHLORIDE(TRIENTINE DIHYDROCHLORIDE)
-
The present invention relates to an improved method for the synthesis of substantially pure 1,2-ethanediamine, N, N'-bis(2-aminoethyl)-dihydrochloride (I). Formula (I). Ν,Ν'-bis (2-aminoethyl)-l,2-ethanediamine dihydrochloride (Trientine dihydrochloride)
- -
-
Page/Page column 18; 19
(2018/11/22)
-
- MOTUPORAMINE DERIVATIVES AS ANTIMICROBIAL AGENTS AND ANTIBIOTIC ENHANCERS AGAINST RESISTANT GRAM-NEGATIVE BACTERIA
-
Motuporamine agents having antimicrobial activity and uses thereof.
- -
-
Paragraph 0175
(2018/10/11)
-
- PREPARATION METHOD OF ETHYLENEAMINE-BASED COMPOUNDS
-
The present invention relates to a method for preparing ethylene amine-based compounds which allows selective preparation of ethylene amine compounds having a higher molecular weight at a high ratio while improving the overall energy efficiency. The method for preparing ethylene amine-based compounds according to the present invention comprises a first reaction step and a second reaction step in which ethylene dichloride reacts with aqueous ammonia so that the molar ratio of ethylene dichloride (EDC) to ammonia may be 1:4-1:10. In the method, ethylene dichloride is introduced in an amount corresponding to 30-70 mol% of the total feed, and the balance amount is introduced in the second reaction step.COPYRIGHT KIPO 2017
- -
-
Paragraph 0068; 0069; 0070; 0086
(2017/10/13)
-
- PROCESS TO CONVERT CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES
-
The present invention relates to a process to convert cyclic alkylene ureas into their corresponding alkylene amines wherein the process is performed by reaction with an amine compound, and wherein the amine compound comprisesa primaryamine,a cyclic secondary amineor a tertiary bicyclic amine.
- -
-
Page/Page column 12
(2017/09/05)
-
- Process for working up reaction outputs from the hydrogenation of EDDN or EDMN
-
A process is disclosed for separating the output from the reaction of EDDN or EDMN with hydrogen in the presence of THF, a catalyst, TETA or DETA, water, and optionally organic compounds having higher and lower boiling points than TETA or DETA. Hydrogen is removed, and the output is supplied to a distillation column DK1 in which an azeotrope, optionally comprising organic compounds with a boiling point lower than TETA or DETA, is removed from the top. A product comprising TETA or DETA is removed from the bottom and passed into a distillation column DK2, removing THF. A stream comprising TETA or DETA passes from the bottom of DK2. The DK1 azeotrope is condensed. Phase separation is induced by the addition of an organic solvent essentially immiscible with water, and the mixture is separated. The organic phase is recycled into DK1 and the water phase is discharged.
- -
-
Page/Page column 43; 44
(2015/02/25)
-
- Amination process for manufacturing amines using catalyst
-
Disclosed is a process for the preparation of an amine (particularly diamines and polyamines) by reacting an alkanolamine or a polyol with ammonia in the presence of a catalyst composed of two active metals from the group of transition metals, namely nickel and chromium supported on a microporous refractory substrate, in a hydrogenated, trickle bed reactor.
- -
-
Paragraph 0044-0049
(2014/08/07)
-
- Unknown
-
A process for preparing amines of the formula (II) [in-line-formulae]R1—NH—CH2—CH2—NH2??(II)[/in-line-formulae]in which R1 is hydrogen or radicals of the formula x is integers from zero to two, by reacting nitriles of the formula (I) [in-line-formulae]R2—NH—CH2—CN??(I)[/in-line-formulae]in which R2 is hydrogen or radicals of the formula and R3 is the NC— or H2N—CH2- radicals and x is integers from zero to two, with hydrogen in the presence of a catalyst in suspension mode or in a fixed bed, wherein the space velocity on the catalyst, based on the catalyst surface area, is 10?6 to 10?4 kg of nitrile of the formula (I) per m2 of catalyst surface area and hour, the catalyst surface area being determined by the BET method.
- -
-
Paragraph 0588; 0589; 0590; 0591
(2013/04/13)
-
- PROCESS FOR PREPARING EDDN AND/OR EDMN AND A PROCESS FOR PREPARING DETA AND/OR TETA
-
A process for preparing EDDN and/or EDMN by a) conversion of FA, HCN and EDA, the conversion being effected in the presence of water,b) depleting water from the reaction mixture obtained in stage a), andc) treating the mixture from stage b) with an absorbent in the presence of an organic solvent, wherein the adsorbent is a solid acidic adsorbent.
- -
-
Paragraph 0559; 0560; 0562; 0563; 0564; 0565; 0566
(2013/03/26)
-
- PROCESS FOR PREPARING EDDN AND EDMN
-
A process for preparing EDDN and/or EDMN by conversion of FA, HCN and EDA, the reaction being effected in the presence of water, and, after the conversion, water being depleted from the reaction mixture in a distillation column, which comprises performing the distillation in the presence of an organic solvent which has a boiling point between water and EDDN and/or EDMN at the distillation pressure existing in the column or which forms a low-boiling azeotrope with water.
- -
-
Paragraph 0572; 0573; 0578; 0579; 0580
(2013/04/10)
-
- METHOD FOR PRODUCING ETHYLENEAMINES
-
The present invention relates to method for producing ethyleneamines that includes: reacting ethylenedichloride with ammonia water under conditions optimizing the molar ratio of ethylenedichloride to ammonia in a defined range to produce amine compounds, ammonium chloride, and water; and isolating the amine compounds, ammonium chloride, and water, respectively. The present invention provides a continuous process for producing ethyleneamines using ethylenedichloride and ammonia by efficiently controlling the composition of the ethyleneamine product in accordance with the supply and demand of ethyleneamines to optimize the distribution of ethyleneamines.
- -
-
Page/Page column 16
(2013/12/03)
-
- Process for preparing TETA and DETA
-
A process for preparing TETA and/or DETA by hydrogenating EDDN and/or EDMN with hydrogen in the presence of a catalyst, which comprises preparing EDDN and/or EDMN from FA, HCN and EDA in the presence of toluene as a solvent and performing the hydrogenation in suspension mode in the presence of THF.
- -
-
Paragraph 0589-0598
(2013/04/13)
-
- PROCESS FOR PREPARING TETA
-
A process for preparing TETA and/or DETA by the action of EDDN and/or EDMN with hydrogen in the presence of a catalyst, wherein the catalyst used is a catalyst of the Raney type and the pressure in the course of hydrogenation is in the range from 170 to 240 bar.
- -
-
Paragraph 0560-0565
(2013/03/26)
-
- METHYL-SUBSTITUTED TETA COMPOUNDS
-
The invention relates to a process for preparing triethylenetetramine substituted by at least one methyl group (Me-TETA or methyl-substituted TETA compounds). Me-TETA is prepared by hydrogenating biscyanomethylimidazolidine (BCMI) in the presence of a catalyst. The present invention further relates to methyl-substituted TETA compounds as such. The present invention further relates to the use of methyl-substituted TETA compounds as a reactant or intermediate in the production of, for example, coatings or adhesives.
- -
-
Page/Page column 7
(2012/05/04)
-
- NOVEL METHOD FOR PRODUCING TETA BY MEANS OF EDDN
-
The invention relates to a process for preparing triethylenetetramine (TETA), which, comprises the following steps: a) reaction of ethylenediamine (EDA) with formaldehyde and hydrocyanic acid (HCN) in a molar ratio of EDA to formaldehyde to HCN of from 1:1.5:1.5 to 1:2:2 to give ethylenediaminediacetonitrile (EDDN),b) hydrogenation of the EDDN obtained in step a) in the presence of a catalyst and a solvent.
- -
-
Page/Page column 8-9; 11
(2010/06/11)
-
- A PROCESS TO SELECTIVELY MANUFACTURE DIETHYLENETRIAMINE (DETA) OR OTHER DESIRABLE ETHYLENAMINES VIA CONTINUOUS TRANSAMINATION OF ETHYLENEDIAMINE (EDA), AND OTHER ETHYLENEAMINES OVER A HETEROGENEOUS CATALYST SYSTEM
-
The present invention reacts ethylenediamine with one or more additional ethyleneamines in the presence of a transamination catalyst to provide a different, preferably more desirable product mix of one or more ethyleneamines.
- -
-
Page/Page column 12; 15-16
(2010/04/28)
-
- METHOD OF MANUFACTURING ETHYLENEAMINES
-
The present invention provides methods of manufacturing ethyleneamines that makes use of an ethyleneamine-generating process that is coupled to a transamination process. The combination of an ethyleneamine-generating process with a transamination process improves the mix flexibility that can be obtained from the single process allowing the production of ethyleneamine compositions having an improved and more desirable product mix.
- -
-
Page/Page column 23-24
(2010/04/28)
-
- PRODUCTION METHOD FOR ETHYLENEAMINE MIXTURES
-
The invention relates to a process for preparing an ethylene amine mixture, which comprises hydrogenating an amino nitrile mixture comprising at least two α-amino nitriles in an amount of at least 5% by weight in each case in the presence of a catalyst and, if appropriate, a solvent.
- -
-
Page/Page column 10
(2010/05/13)
-
- METHODS OF MAKING CYCLIC, N-AMINO FUNCTIONAL TRIAMINES
-
The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
- -
-
Page/Page column 26-27
(2010/04/28)
-
- METHOD FOR PRODUCING TRIETHYLENETETRAMINE
-
The invention relates to a process for preparing triethylenetetramine (TETA), which comprises hydrogenating ethylenediaminediacetonitrile (EDDN) in the presence of a catalyst and a solvent.
- -
-
Page/Page column 8
(2010/03/02)
-
- METHOD FOR PRODUCING TETRAETHYLENEPENTAMINE
-
The invention relates to a process for preparing tetraethylenepentamine (TEPA) by hydrogenation of diethylenetriaminediacetonitrile (DETDN) over a catalyst. If appropriate, DETDN can also be present as a constituent of an amino nitrile mixture which additionally comprises diethylenetriaminemonoacetonitrile (DETMN).
- -
-
Page/Page column 8
(2010/03/02)
-
- Low metal loaded, alumina supported, catalyst compositions and amination process
-
The present invention provides catalyst compositions useful for transamination reactions. The catalyst compositions have a catalyst support that includes transitional alumina, use a low metal loading (for example, less than 25 wt. %), and do not require the presence of rhenium. The catalyst compositions are able to advantageously promote transamination of a reactant product (such as the transamination of EDA to DETA) with excellent activity and selectivity, and similar to transaminations promoted using a precious metal-containing catalyst.
- -
-
Page/Page column 9-12
(2010/06/16)
-
- Method for Producing Ethylene Amines
-
Processes comprising: providing a starting material comprising ethylenediamine; and reacting the starting material in the presence of a heterogeneous transition metal catalyst to form one or more ethylene amines; wherein the catalyst comprises a catalytically active composition, which prior to treatment with hydrogen, comprises a mixture of oxygen-containing compounds of aluminum, copper, nickel and cobalt; and wherein the catalyst is present as one or more shaped catalyst particles selected from spheres, extrudates, pellets and other geometries, wherein the sphere or extrudate has a diameter of a height of a′ of a′ is the external surface area per unit volume (mms2/mmp3), as defined by a ′ = A p V p where Ap is the external surface area of the catalyst particle (mms2) and Vp is the volume of the catalyst particle (mmp3).
- -
-
Page/Page column 4
(2008/12/08)
-
- TREATMENT OF MITOCHONDRIA-RELATED DISEASES AND IMPROVEMENT OF AGE-RELATED METABOLIC DEFICITS
-
Treatment of mitochondrial related conditions in mammals with antagonists or chelating agents of copper (II), preferably tetramines or penicillamines. These agents affect TGF-beta, Smad 4, collagen IV, cytochrome C oxidase and erectile dysfunction.
- -
-
Page/Page column 53; 73; 80; 83; 86; 91-92; 95; 97-98
(2008/06/13)
-
- METHOD FOR PRODUCING ETHYLENEAMINES
-
The invention relates to the production ethyleneamines by reacting monoethanolamine (MEOA) with ammonia in the presence of a catalyst inside a reactor (1) and by separating the resulting reaction discharge. During separation, the ethylenediamine (EDA) obtained is reacted inside a separate reactor (2) in the presence of a catalyst to form diethylenetriamine (DETA), and the resulting reaction discharge is fed to the separation of the reaction discharge resulting from the reactor (1).
- -
-
Page/Page column 10; 11
(2008/06/13)
-
- Process for the preparation of 1,4,7,10-tetraazacyclododecane
-
1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.
- -
-
Page/Page column 6
(2008/06/13)
-
- Alkyl glycidyl ether-capped polyamine foam control agents
-
A method for controlling the foaming of an aqueous organic compound-containing composition by the incorporation of a foam controlling amount of a compound of the formula: where n and m are 2 or 3, ???x is 1-6, and ???R' is a C4 to C22 alkyl group, where R' is a C4 to C22 alkyl group, the compound generating an initial foam height at least 30% less than a 0.1 wt% aqueous solution of dioctyl sodium sulfosuccinate (DOSS) when added at 0.1 wt% to the DOSS solution.
- -
-
-
- Phenylglyoxal for polyamines modification and cyclam synthesis
-
The bis-aminals obtained by tetraamine and phenylglyoxal condensation display various behaviours such as equilibrium between different configurations, rearrangements that lead to lactam derivatives, or amine deprotection. Our investigations about them were focused on three different linear amines, and then extended to polyazacycloalkanes cyclen and cyclam. Cyclam was also synthesised with the bis-aminals issued from condensation of linear polyamines with phenylglyoxal. The lactam derivatives described here were moreover, employed for the mono-N-functionalisation of tetraamines by phenyl-acetic acid group.
- Tripier, Rapha?l,Chuburu, Fran?oise,Le Baccon, Michel,Handel, Henri
-
p. 4573 - 4579
(2007/10/03)
-
- Tetramine treatment of neurological disorders
-
2,3,2 Tetramine (3,7-diazanonane-1,9-diamine) is propounded for the treatment of Parkinson's Disease and dementias characterized by mitochondrial damage in view of this compound's ability to completely neutralize the dopainine-depriving effect of MPTP in laboratory animals up to 12 hours post MPTP injection, and to retain partial protection at suboptimal tissue levels for up to 36 hours. The effect of injecting combinations of MPTP and/or reducing agents and/or xenobiotics and/or depigmenting agents on Dopamine, Norepinephrine, Serotonin and Epinephrine levels demonstrated that MPTP and MPP+ act as reducing agents that mobilize copper and calcium, and sequester iron, and that the vulnerability of dopamine to these types of neurotoxins and to xenobiotics and metals can be corrected by administration of 2,3,2 tetramine that appears to redistribute metals between diverse storage pools and free metals in cytosol and regulate receptor mediated events, among other antidotal effects analogous to those of some of the endogenous polyamines.
- -
-
-
- Process for the preparation of 1,4,7,10-tetraazacyclododecane
-
A process for the preparation of 1,4,7,10-tetraazacyclododecane of formula (I), starting from decahydro-2a,4a,6a,8a-tetraazacyclopent?fg!acenaphthylene of formula (II): comprising the direct step of hydrolysis in aqueous solution, in conditions of slightly acid, neutral or slightly basic pH, with a primary diamine of formula (V), in which x ranges between 0 and 2, and Q is --CH2 CH(OH)CH2 --, --(CH2)2 NH(CH2)2 --, or --?(CH2)2 NH!2 (CH2)2, when x is 1, or Q is --CH2 -- when x is 2. STR1
- -
-
-
- Polyamino salts of alpha-hydroxyacids, alpha-ketoacids and related compounds
-
Cosmetic compositions are described wherein α-hydroxyacids, α-ketoacids and related compounds are formed into amine salts through neutralization with a multi-amine functionalized polymer. Particularly preferred are glycolic acid and lactic acid salts of poly(ethylenimine).
- -
-
-
- Triphendioxazine dyestuffs
-
The novel triphendioxazine dyestuffs of the formula STR1 in which the substituents R, R', T1, T2, X, Y and n have the meanings given in the description are highly suitable for the dyeing and printing of cellulose-containing or amido-containing material.
- -
-
-
- Cascade polymer bound chelating compounds, their chelates and conjugates, processes for their production, and pharmaceutical agents containing them
-
Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
- -
-
-
- Process for the dyeing of leather with anionic dyes and polyaminoamide resin as dyeing auxiliary
-
To improve the affinity of anionic dyestuffs in the dyeing of leather materials, polycondensation products consisting of at least one amine of the formula STR1 in which the radicals have the meanings mentioned in the description with one dicarboxylic acid and, if desired, ω-aminocarboxylic acid or its lactam are highly suitable.
- -
-
-
- NUCLEOPHILIC CLEAVAGE AND FORMATION OF SATURATED HETEROCYCLES. IX. KINETICS OF THE AMINATION OF 1-AZIRIDINE
-
1.Enlarging the aminoethyl substituent at the heteroatom of the aziridine ring results in a decrease in reactivity and an increase in substrate selectivity towards nucleophilic cleavage by amines. 2.The reactivity of amines in the nucleophilic cleavage of 1-aziridine is largely governed by the steric accessibility of the nitrogen atoms of the nucleophile.Amino groups in which the environment of the reaction site is the same have similar reactivities.
- Bobylev, V. A.,Dalin, A. R.,Borisenko, I. V.,Kamskaya, O. I.
-
p. 1003 - 1007
(2007/10/02)
-
- σ-Bonded organochromiuin(III) complexes. 3. Decomposition in acid solution of chromium(III) complexes containing pyridylmethyl and polydentate amine ligands
-
The decomposition of σ-bonded (pyridylmethyl)chromium complexes, 2- and 3-NC5H4CH2CrLn (L = dap (1,3-diaminopropane), dien (diethylenetriamine), trien (triethylenetetramine), and [15]aneN4 (tetraazacyclopentadecane)), was investigated in aqueous perchloric acid under aerobic conditions. Except for L = 15[ane]N4, Cr-C bond scission was preceded by complete aquation in the case of the 2-isomers and partial aquation for the 3-isomers. The aquation rates were compared with those of inorganic chromium complexes containing similar amine ligands. Kinetic data for the Cr-C bond cleavage were correlated with those for the analogous ethylenediamine (en) and aquo (H2O) systems. The activation parameters and product studies are in support of a homolytic pathway for the Cr-C bond cleavage.
- Crouse, Karen,Goh, Lai-Yoong
-
p. 478 - 484
(2008/10/08)
-
