- Positron Emission Tomography Imaging of Staphylococcus aureus Infection Using a Nitro-Prodrug Analogue of 2-[18F]F- p-Aminobenzoic Acid
-
Deep-seated bacterial infections caused by pathogens such as Staphylococcus aureus are difficult to diagnose and treat and are thus a major threat to human health. In previous work we demonstrated that positron emission tomography (PET) imaging with 2-[18
- Daryaee, Fereidoon,Li, Yong,Meimetis, Labros,Noh, Doyoung,Si, Yuanyuan,Smith-Jones, Peter M.,Tonge, Peter J.,Turkman, Nashaat,Walker, Stephen G.,Yoon, Grace E.
-
-
Read Online
- POSITRON IMAGING TOMOGRAPHY IMAGING AGENT COMPOSITION AND METHOD FOR DETECTION OF BACTERIAL INFECTION
-
This invention provides a composition comprising the compound having the structure: ethyl 2-[19F]F-4-nitrobenzoate, and at least one acceptable carrier. This invention also provides a method of detecting the presence of or location of bacteria
- -
-
Page/Page column 42
(2021/11/13)
-
- Preparation method of 4-chloro-2-fluoro-5-nitroacetophenone
-
The invention discloses a preparation method of 4-chloro-2-fluoro-5-nitroacetophenone, the preparation method is characterized in that m-fluoroaniline is taken as an initial raw material, and the 4-chloro-2-fluoro-5-nitroacetophenone is obtained through acetylation amino protection, Friedel-Crafts acylation reaction, hydrolysis reaction, Sandmeyer reaction and final nitration, and the preparationmethod has the advantages of easily available raw materials, low reaction condition requirement, few side reactions and high yield.
- -
-
Paragraph 0026-0029
(2020/01/25)
-
- P -Toluenesulfonic Acid Induced Conversion of Fluorinated Trimethylsilylethynylanilines into Aminoacetophenones: Versatile Precursors for the Synthesis of Benzoazaheterocycles
-
A simple and efficient approach to the synthesis of fluorinated amino-substituted acetophenones in good to excellent yields is reported. The heart of the proposed method consists of conversion of a Me 3 Si-C≡C- moiety into a MeC(=O)- group in the presence of p -tolu ene sulfonic acid (p -TSA) passing a stage of ethynylaniline formation. The reaction is metal-free, proceeds under mild conditions, and uses readily available starting compounds (trimethylsilylarylacetylene derivatives). The reaction provides access to amino-substituted acetophenones, which may serve as precursors for the synthesis of polyfluorinated azaheterocycles, having potential anticarcinogenic activity.
- Politanskaya, Larisa,Tretyakov, Evgeny
-
p. 555 - 564
(2017/11/03)
-
- Anthranilonitrile derivatives as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals
-
There are provided novel anthranilonitrile derivatives and related compounds which are useful for promoting growth, improving feed efficiency and for increasing the lean meat to fat ratio of warm-blooded animals.
- -
-
-
