Structure-activity relationships of N-phenyl-N′-benzothiazol-6-ylurea synthetic derivatives: Cytokinin-like activity and adventitious rooting enhancement
Some years ago we demonstrated the cytokinin-like activity of the synthetic N-phenyl-N′-benzothiazol-6-ylurea (PBU) and a relevant adventitious rooting adjuvant activity of symmetric urea derivatives devoid of any cytokinin- or auxin-like activity per se. Here we report the synthesis and the biological activity evaluation of nine symmetric or asymmetric ureas/thioureas, structurally related to PBU. None of them show cytokinin-like activity, while we demonstrate for the first time that PBU interacts with Arabidopsis cytokinin receptor CRE1/AHK4 in a heterologous bioassay system. Among the PBU derivatives, all the symmetric ureas/thioureas show an adventitious rooting adjuvant activity in various bioassays, confirming that this activity is strictly dependent on their chemical structure.
Rolli, Enrico,Incerti, Matteo,Brunoni, Federica,Vicini, Paola,Ricci, Ada
p. 159 - 165
(2012/03/27)
HETEROAROMATIC UREAS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)
Compounds of formula (I): are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).
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Page/Page column 41-42
(2010/02/11)
Synthesis and Reactions of Azido-benzothiazoles and -benzothiophens; Novel Thiazolobenzoxazoles and Dihydrothienobenzoxazoles
6-Azidobenzothiazole and its 2-methyl and 2-methylthio-derivatives were prepared from the corresponding amine and gave the thiazolobenzoxazoles (8)-(10), on thermolysis in a polyphosphoric-acetic acid mixture. 6,7-Dihydro-2-methylthienobenzoxazole 8,8-dioxide (12) was prepared similarly.An improved method of synthesis of 2-fluoro-6-nitrobenzothiazole is reported.
Gallagher, Peter T.,Iddon, Brian,Suschitzky, Hans
p. 2358 - 2361
(2007/10/02)
Synthesis of antimicrobial agents. I. Synthesis and antimicrobial activities of thiazoloquinoline derivatives
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Suzuki,Tanaka,Dohmori
p. 1 - 11
(2007/10/04)
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