Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays
A major problem associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of HIV is their lack of resilience to mutations in the reverse transcriptase (RT) enzyme. Using structural overlays of the known inhibitors efaviren
Jones, Lyn H.,Allan, Gill,Barba, Oscar,Burt, Catherine,Corbau, Romuald,Dupont, Thomas,Kn?chel, Thorsten,Irving, Steve,Middleton, Donald S.,Mowbray, Charles E.,Perros, Manos,Ringrose, Heather,Swain, Nigel A.,Webster, Robert,Westby, Mike,Phillips, Chris
experimental part
p. 1219 - 1223
(2010/01/07)
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