- Alpha-N-methylhistidine intermediate and preparation method thereof
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The invention relates to an alpha-N-methylhistidine intermediate and a preparation method thereof. The intermediate has a chemical structure as shown in a formula I, wherein R is selected from the group consisting of methyl, phenyl, p-methylphenyl, o-methylphenyl, meta-methylphenyl, 2,4-dimethylphenyl, 2-nitrophenyl, 4-nitrophenyl, 2,4-dinitrophenyl, p-methoxyphenyl, 2,4-dimethoxyphenyl or benzyl; and PG is a protection group. The alpha-N-methylhistidine intermediate can successfully realize subsequent chemical reactions and obtain N-methylhistidine with extremely-high optical purity; meanwhile, subsequent protection groups are easy to be removed, and decomposition of products and damage of optical purity may not be caused; and more importantly, the preparation method for the alpha-N-methylhistidine intermediate is simple and solves problems of difficult production and incapable mass production of alpha-N-methylhistidine in the prior art.
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Paragraph 0047-0049
(2017/01/26)
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