- A 5-hydroxytryptamine receptor agonist, a preparing method thereof and uses of the receptor agonist
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A novel crystal of (3a[alpha],4[beta],7[beta],7a[alpha])-hexahydro-2-[4[4-(2-pyrimidinyl)-1-(piperazinyl)]-butyl]-4,7-methylene-1H-isoindole-1,3(2H)-dione citrate monohydrate, a preparing method thereof and uses of the crystal are disclosed. The molecular formula of the (3a[alpha],4[beta],7[beta],7a[alpha])-hexahydro-2-[4[4-(2-pyrimidinyl)-1-(piperazinyl)]-butyl]-4,7-methylene-1H-isoindole-1,3(2H)-dione citrate monohydrate is CHN5O.C6H8O.H2O. The novel crystal increases stability and solubility of products at present, thus facilitating product preparation and application and increasing medicine safety and effectiveness.
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Paragraph 0073; 0074
(2017/03/14)
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- Tandospirone citrate compound
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The invention provides a tandospirone citrate compound and further provides a preparation method, pharmaceutical composition and application of the tandospirone citrate compound. The tandospirone citrate compound exists in the form of crystals and is stable in property and high in purity, water solubility is obviously improved compared with an existing product, and an effective solving way is provided for improving the bioavailability and safety of medicine. A preparation prepared from the tandospirone citrate compound is good in dissolving effect, the medicine application effect can be guaranteed, and the tandospirone citrate compound is suitable for medicine use. In addition, the compound is simple in preparation process, high in yield and suitable for industrial production.
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Paragraph 0035; 0036; 0037; 0038; 0039
(2016/12/22)
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