- Synthesis of 6,6-difluorohomopiperazines via microwave-assisted detosylation
-
[1,4]-Diazepan-6-ols are easily oxidized to ketones using Swern or Dess-Martin oxidation conditions. The fluorination of these [1,4]-diazepanones with diethylaminosulfur trifluoride (DAST) affords gem-difluorohomopiperazines. Detosylation under microwave conditions represents a rapid method to access the corresponding amines in high yields.
- Wellner, Eric,Sandin, Helena,P??kk?nen, Leila
-
-
Read Online
- Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
-
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: STR1 wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.
- -
-
-
- Methods of preparing manganese complexes of nitrogen-containing macrocyclic ligands
-
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: STR1 wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.
- -
-
-