IMPROVED PROCESS FOR THE PREPARATION OF (S)-PREGABALIN
The present invention provides a process for resolving racemic pregabalin to S-pregabalin by using a chiral acid to form a pregabalin salt, purifying the salt to obtain a purified S-pregabalin salt then neutralizing the salt to obtain S-pregabalin having good chiral purity.
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Page/Page column 8-9
(2009/09/04)
NOVEL RESOLUTION PROCESS FOR PREGABALIN
Present invention relates to a novel and improved process for the resolution of racemic pregabalin of formula (I) into (S)-(+)-pregabalin [(S)-(+)-3-aminomethyl-5-methylhexanoic acid] of formula (III) via the novel acid addition salt [(S)-(+) 3-aminomethyl-5-methylhexanoic acid, (-)-O, O'-di-p-toluoyl-L-tartaric acid salt] of formula (II). (S)-(+)-pregabalin of formula-III has analgesic, anticonvulsant and anxiolytic properties and hence is of great therapeutic significance.
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Page/Page column 16-17
(2009/05/29)
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