The present invention provides 2-aryl or heteroaryl indole derivatives which are ASIC channel modulators, pharmaceutical compositions containing such compounds, and methods of using them as therapeutic agents.
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Page/Page column 33-34
(2009/05/29)
Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)
A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.
Kuduk, Scott D.,Chang, Ronald K.,Wai, Jenny M.-C.,Di Marco, Christina N.,Cofre, Victoria,DiPardo, Robert M.,Cook, Sean P.,Cato, Matthew J.,Jovanovska, Aneta,Urban, Mark O.,Leitl, Michael,Spencer, Robert H.,Kane, Stefanie A.,Hartman, George D.,Bilodeau, Mark T.
scheme or table
p. 4059 - 4063
(2010/04/05)
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