- Enantioselective Synthesis of 1,2-Dihydronaphthalenes via Oxidative N-Heterocyclic Carbene Catalysis
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1,2-Dihydronaphthalenes are important molecules in both medicinal and synthetic chemistry, but methods for the catalytic asymmetric construction of this class of molecules are limited. The diastereo- and enantioselective N-heterocyclic carbene-catalyzed cascade annulation reactions using benzodiketones and enals under oxidative conditions, which afford a variety of 1,2-dihydronaphthalenes with two adjacent stereocenters in up to 99% yield, with >20:1 dr, and up to 99% ee, are reported. Furthermore, the product can be easily transformed to a series of useful compounds such as alcohol, amide, and epoxide.
- Perveen, Saima,Zhao, Zhifei,Zhang, Guoxiang,Liu, Jian,Anwar, Muhammad,Fang, Xinqiang
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p. 2470 - 2473
(2017/05/24)
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- Facile benzannulation of isocoumarins in the efficient synthesis of diversified 1,3-disubstituted isoquinolines
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An efficient and facile one-pot synthesis of 1,3-disubstituted isoquinolines 3 was accomplished from 3-substituted isocoumarins 1 through diketones, formed in situ via the Grignard reaction, in the presence of ammonium acetate, montmorillonite K-10 catalyst, and ethanol solvent. Springer Science+Business Media B.V. 2011.
- Manivel,Prabakaran,Khan, F. Nawaz,Jin, Jong Sung
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experimental part
p. 347 - 357
(2012/05/20)
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