- Catalytic Amination of β-(Hetero)arylethyl Ethers by Phosphazene Base t-Bu-P4
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We describe the catalytic amination of β-(hetero)arylethyl ethers with amines using the organic superbase t-Bu-P4 to obtain β-(hetero)arylethylamines. The reaction has a broad substrate scope and allows the transformations of electron-deficient and electron-neutral β-(hetero)arylethyl ethers with various amines including pyrrole, N-alkylaniline, diphenylamine, aniline, indole, and indoline derivatives. Mechanistic studies indicate a two-reaction pathway of MeOH elimination from the substrate to form a (hetero)arylalkene followed by the hydroamination of the alkene.
- Shigeno, Masanori,Nakamura, Ryutaro,Hayashi, Kazutoshi,Nozawa-Kumada, Kanako,Kondo, Yoshinori
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p. 6695 - 6699
(2019/09/07)
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- First Cobalt(I)-catalysed Heterocyclotrimerization of Ethyne with Nitriles to Pyridines in Water under Mild Conditions
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In water the synthesis of substituted pyridines with cobalt(I)-complexes is carried out at room temperature and normal pressure with very high product selectivity in the presence of light.
- Heller, Barbara,Oehme, Guenther
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p. 179 - 180
(2007/10/02)
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- Photoinduced Alkoxylation of 2-Vinylpyridinium Ion
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Photoirradiation of 2-vinylpyridine in acidic methanol afforded methyl 2-(2-pyridyl)ethylether in a high yield.Reactions in acetic ethanol and 2-propanol also provided the corresponding alkoxyl derivatives along with a considerable amount of 2-ethylpyridine.It was suggested that photoinduced intramolecular charge-shift from the pyridinium ion moiety into the vinyl group initiates the regioselective nucleophilic addition of alcohol.
- Ishida, Akito,Uesugi, Tatsumi,Takamuku, Setsuo
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p. 1580 - 1582
(2007/10/02)
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- Alkylation of Pyridine in Free Radical Chain Reactions Utilizing Alkylmercurials
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Pyridines or N,N,N',N'-tetramethyl-p-phenylenediamine will undergo a photostimulated free radical chain reaction with alkylmercury halides or carboxylates, yielding ring alkylated substitution products.Alkene mercuration products (R1CH(Y)CH(R2)HgX with Y=HO, RO, CH3CONH; X=Cl, CH3CO2, CF3CO2) can be used without isolation for the alkylation reaction
- Russell, Glen A.,Guo, Deliang,Khanna, Rajive K.
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p. 3423 - 3425
(2007/10/02)
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- SYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIDINES AND DIPYRIDYL-SUBSTITUTED COMPOUNDS WITH THE AID OF LOW-VALENCE COMPOLEXES
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The possibility of the preparation of oxygen, nitrogen, and sulfur-containing pyridines and dipyridyl-substituted compounds by the cyclocotrimerization of substituted propionitriles with acetylene under the influence of a Co(2-ethylhexanoate)2-Al(C2H5)3 catalyst was demonstrated.It was established that the nature of the heteroatom in substituted propionitriles has virtually no effect on the direction of the reaction.
- Selimov, F. A.,Khafizov, V. R.,Dzhemilev, U. M.
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p. 290 - 295
(2007/10/02)
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