- Synthesis of reference substances for highly polar metabolites of nitroaromatic compounds
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Transformation processes of nitroaromatic compounds (NAC) lead to polar and highly hydrophilic metabolites. For the unequivocal identification of proposed metabolites reference substances are needed. Since most of them are not commercially available, their synthesis was done in our group. In many cases no satisfying synthesis schemes were found in the literature. In this communication, we therefore describe the preparation, structural elucidation and separation of 17 compounds. Many of the newly synthesized analytes were found in various water samples from a former ammunition plant.
- Schmidt, Torsten C.,Steinbach, Klaus,Buetehorn, Ulf,Heck, Kerstin,Volkwein, Ute,Stork, Gottfried
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p. 3119 - 3130
(2007/10/03)
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- RADICAL ANIONS OF AROMATIC COMPOUNDS XIX. INFLUENCE OF SALTS OF MULTIPLY CHARGED CATIONS ON THE STRUCTURE OF RADICAL ANIONS AND THE ORIENTATION OF PARTIAL REDUCTION IN SOME DI- AND TRI-NITROBENZENES
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Addition of Ba2+ and Al3+ salts in the partial reduction of a number of 1-substituted 2,4-di- and 2,4,6-tri-nitrobenzenes (substituents: CO2H, Cl) with the Ti3+-EDTA complex leads to a substantial increase in the formation of the orthoamino derivative relative to that of the para compound.This fact is in keeping with the character of the influence of additions of barium chloride on the proportions of the isomeric forms of the 2,4-dinitrobenzoic acid radical anion, which differ in the localization of the unpaired electron on the ortho- or para-nitro group respectively.An analogous effect of change in the orientation of the partial reduction can be obtained when titanium trichloride is used as reductant and no chelating agent is added.
- Bil'kis, I. I.,Uskov, S. I.,Shteingarts, V. D.
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p. 1694 - 1699
(2007/10/02)
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