- Synthesis of biaryls by Pd-catalyzed decarboxylative homo- and heterocoupling of substituted benzoic acids
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By carefully choosing the right substrate ratio, catalyst combination, and base, symmetrical and unsymmetrical biaryls can be readily synthesized through the Pd-catalyzed decarboxylative homo- and heterocoupling of substituted benzoic acids. The reaction gave the desired products in 40-90% yield and is compatible with 2-nitro-, 2-methoxy-, 2-fluoro-, and 2-chloro-substituted benzoic acids. With the correct substrate ratio, catalyst combination, and base, symmetrical and unsymmetrical biaryls can be readily synthesized through the Pd-catalyzed decarboxylative homo- and heterocoupling of substituted benzoic acids.
- Xie, Kai,Wang, Sizhuo,Yang, Zhiyong,Liu, Jidan,Wang, Anwei,Li, Xiujian,Tan, Ze,Guo, Can-Cheng,Deng, Wei
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supporting information; experimental part
p. 5787 - 5790
(2011/11/06)
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