- An efficient oxidation of 2-aryl-1,2,3,4-tetrahydro-4-quinolones employing ferric chloride hexahydrate-methanol: Synthesis of naturally occurring 4-alkoxy-2-arylquinolines
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A simple, inexpensive and efficient oxidation of 2-aryl-1,2,3,4-tetrahydro- 4-quinolones has been carried out by employing FeCl3·6H 2O-methanol under mild conditions. This method has been investigated for the synthesis of an endothel
- Kumar, K. Hemanth,Muralidharan,Perumal
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- Palladium catalyzed hydrodefluorination of fluoro-(hetero)arenes
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Palladium catalyzed hydrodefluorination was developed for fine-tuning the properties of fluoro-(hetero)aromatic compounds. The robust reaction can be set up in air, requires only commercially available components, and tolerates a variety of heterocycles and functionalities relevant to drug discovery. Given the prevalence of fluorine incorporation around metabolic hotspots, the corresponding deuterodefluorination reaction may prove useful for converting fluorinated libraries to deuterated analogues to suppress the oxidative metabolism by kinetic isotope effects.
- Gair, Joseph J.,Grey, Ronald L.,Giroux, Simon,Brodney, Michael A.
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supporting information
p. 2482 - 2487
(2019/04/10)
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- Lewis Acid Promoted Oxonium Ion Driven Carboamination of Alkynes for the Synthesis of 4-Alkoxy Quinolines
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Lewis acid mediated multisegment coupling cascade is designed for the synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion triggered alkyne carboamination sequence involving C-C and C-N bond formations. Cyclic ether fused-quinolines cou
- Gharpure, Santosh J.,Nanda, Santosh K.,Adate, Priyanka A.,Shelke, Yogesh G.
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p. 2067 - 2080
(2017/02/26)
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- A modified Niementowski reaction for the synthesis of 4-hydroxyquinoline and its realted compounds
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The iminoketene generated from anthranilic acid and thionyl chloride reacted with ketones to afford 4-hydroxyquinoline derivatives in good yields.
- Son, Jae Keun,Kim III, Seung,Jahng, Yurndong
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p. 1981 - 1986
(2007/10/03)
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- Enzymatic resolution of 1-amino-2-vinylcyclopropyl caboxylic acid methyl ester
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An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase?, is disclosed.
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- An Unusual Base-Mediated Cyclization of Ketimines Derived from 2-(Trifluoromethyl)aniline That Involves the Trifluoromethyl Group: An Expedient Route to 2-Arylquinolines
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6-(Substituted methylene)-N-(arylalkylidene)-2,4-cyclohexadien-1-imines, such as 13, 17, and 21 (Scheme II) are suggested intermediates in a novel synthetic route to 2-arylquinolines based on the reaction of trifluoromethyl-substituted ketimines, such as
- Strekowski, Lucjan,Wydra, Roman L.,Cegla, Marek T.,Czarny, Agnieszka,Harden, Donald B.,et al.
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p. 4777 - 4779
(2007/10/02)
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- Synthesis of Simple Quinoline Alkaloids. A Novel Quinazoline Synthesis
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2-Alkyl (aryl), 4-amino-substituted quinolines are prepared in two steps by cycloaddition of 2-nitrobenzaldoximes with acetylenes and subsequent reductive cleavage of the intermediate isoxazole in acetic acid.Diazotization of the 4-aminoquinolines gives t
- Thomsen, Ib,Torssell, Kurt B. G.
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p. 309 - 313
(2007/10/02)
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