Palladium-catalyzed cross-coupling of B-Benzyl-9-borabicyclo[3.3.1]nonane to furnish methylene-linked biaryls
(Chemical Equation Presented) Benzylboranes are noticeably uncommon partners within Suzuki-Miyaura coupling reactions. B-Benzyl-9-BBN was successfully coupled to a range of aryl/heteroaryl bromides, chlorides, and triflates to give pharmacologically important methylene-linked biaryl structures. Activated, deactivated, and sterically hindered substrates were successfully coupled in high yield using Pd(PPh3)4 or Pd(OAc)2 with SPhos as the catalyst system.
Flaherty, Alice,Trunkfield, Amy,Barton, William
p. 4975 - 4978
(2007/10/03)
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