- STEREOSELECTIVE SYNTHESIS OF BETA-NUCLEOSIDES
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A process of stereoselectively synthesizing β-nucleoside of formula (I), e.g., 2'-deoxy-2,2'-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R1, R2, R3, R4, and L as defined in the specification, with a nucleobase derivative in the presence of an oxidizing agent.
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- NOVEL SYNTHESIS OF BETA-NUCLEOSIDES
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This invention relates to a process of stereoselectively synthesizing β-nucleoside, e.g., 2′-deoxy-2,2′-difluorocytidine.
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Page/Page column 4; 7
(2009/05/28)
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