- For the treatment of tumor macrocyclic derivatives (by machine translation)
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The invention discloses a method for modulating protein kinase activity, and is used for the treatment or prevention of protein kinase related disorders. Specifically, the invention relates to a method for the treatment of tumor of the macrocyclic derivatives, which belongs to the regulating Anaplastic lymphoma kinase (ALK) active compound, and provides the preparation method of the compound, and the compound used for the treatment or prevention of diseases associated with the ALK pharmaceutical use. (by machine translation)
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Paragraph 0131-0132; 0204-0205
(2017/07/20)
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- Synthesis method of 2-chloride-4-fluoride-5-nitrobenzoic acid
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The invention relates to a synthesis method of 2-chloride-4-fluoride-5-nitrobenzoic acid. The synthesis method is characterized by including the steps: adding 2-chloride-4 fluorobenzoic acid and a catalyst into concentrated sulfuric acid; dripping nitroso
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Paragraph 0014; 0015; 0016; 0017
(2017/07/19)
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- BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE
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Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
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Page/Page column 56
(2013/07/25)
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- Inhibitors of viral replication, their process of preparation and their therapeutical uses
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The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
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Page/Page column 50
(2012/11/06)
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- INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
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The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
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Page/Page column 69
(2012/11/06)
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- PROCESS FOR THE PREPARATION OF BENZOIC ACID DERIVATIVES VIA A NEW INTERMEDIATE OF SYNTHESIS
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The object of the invention is the preparation of 2-chloro-4-fluoro-5-nitrobenzoic acid and derivatives thereof, by nitration of 2-chloro-4-fuorobenzotrichloride and the conversion of the novel synthetic intermediate thus obtained into its acid form or de
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Page/Page column 6
(2009/06/27)
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- HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS
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Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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Page/Page column 58
(2010/11/30)
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- BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS
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The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
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Page/Page column 54-55
(2010/11/28)
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- New 6-nitroquinolones: Synthesis and antimicrobial activities
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Pursuing our searches on quinolonecarboxylic acids we used a simple three-step one pot procedure to synthesize novel 1,7-disubstituted-6- nitroquinolones. The new derivatives were tested against Mycobacterium tuberculosis and Mycobacterium avium complex (
- Sbardella, Gianluca,Mai, Antonello,Artico, Marino,Setzu, Maria Giovanna,Poni, Graziella,La Colla, Paolo
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p. 463 - 471
(2007/10/03)
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- Uracil substituted phenyl sulfamoyl carboxamides
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Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur; X1=H, halogen, C1-C4-alkyl; X2=H, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl; X3=H, CN, C1-C6-alkyl, C1-C6-alkoxyalkyl, C3-C7-cycloalkyl, C3-C6-alkenyl, C3-C6-alkynyl, optionally substituted benzyl; R1, R2=H, halogen, optionally substituted hydroxy, C1-C10-alkyl, C2-C10-alkenyl, C3-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl or C5-C7-cycloalkenyl, or R1+R2 together with the atom to which they are attached form a 3- to 7-membered heterocyclic ring; Q is selected from Q1 to Q40 as defined in the description. Use: As herbicides; for the desiccation/defoliation of plants.
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- Pyridazin-3-one derivatives, their use, and intermediates for their production
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Novel hydrazones of formula [2] having the following structural formula are provided, which are useful intermediates to form active ingredients of herbicides, wherein R3 is hydrogen, alkyl, haloalkyl, or alkoxy alkyl; and Q is [Q-1], [Q-2], [Q-
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Page column 60-61
(2010/01/30)
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- Pyridazin-3-one derivatives, their use, and intermediates for their production
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PCT No. PCT/JP96/02311 Sec. 371 Date Jan. 30, 1998 Sec. 102(e) Date Jan. 30, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/07104 PCT Pub. Date Feb. 27, 1997Novel pyridazin-3-one derivatives of formula [1] are provided, which are useful as active ingredie
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- Heterocyclic herbicides
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Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein, Q is and W,X,R1-R7are as defined in the disclosure. Also disclosed are composi
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- Herbicidal tricyclic heterocycles
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Compounds of Formula I having herbicidal utility are disclosed: STR1 wherein Q, R1, R2, V, m and p are defined in the text, including compositions containing such compounds, and a method for controlling weeds employing such compounds.
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- Novel N-imides
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A convenient method for the synthesis of N--3,4,5,6-tetrahydrophthalimides using benzyl triflates is described.
- Wheeler, Thomas N.,Craig, Todd A.,Morland, Robert B.,Ray, John, A.
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p. 883 - 887
(2007/10/02)
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