- Formal Synthesis of Anticoagulant Drug Fondaparinux Sodium
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The practical formal synthesis of the anticoagulant drug fondaparinux sodium 1 was accomplished using an optimized modular synthetic strategy. The important pentasaccharide 2, a precursor for the synthesis of fondaparinux sodium, was synthesized on a 10 g scale in 14 collective steps with 3.5% overall yield from well-functionalized monosaccharide building blocks. The strategy involved a convergent [3 + 2] coupling approach, with excellent stereoselectivity in every step of glycosylation from the monosaccharide building blocks. Efficient routes to the syntheses of these fully functionalized building blocks were developed, minimizing oligosaccharide stage functional-group modifications. The syntheses of all building blocks avoided rigorous reaction conditions and the use of expensive reagents. In addition, common intermediates and a series of one-pot reactions were employed to enhance synthetic efficiency, improving the yield considerably. In the monosaccharide-to-oligosaccharide assembly reactions, cheaper activators (e.g., NIS/TfOH, TESOTf, and TfOH) were used to facilitate highly efficient glycosylations. Furthermore, crystallization of several monosaccharide and oligosaccharide intermediates significantly simplified purification procedures, which would be greatly beneficial to the scalable synthesis of fondaparinux sodium.
- Dai, Xiang,Liu, Wentao,Zhou, Qilong,Cheng, Chunwei,Yang, Chao,Wang, Shuqing,Zhang, Min,Tang, Pei,Song, Hao,Zhang, Dan,Qin, Yong
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- New process method for preparing fondaparinux sodium
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The invention discloses a new process method for preparing fondaparinux sodium. A fondaparinux sodium crude product is prepared from total protective pentose through ester hydrolysis reaction, methylesterification, hydrogenation, sulfonated reaction and t
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Paragraph 0041; 0042
(2018/07/15)
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- A pentose compound of intermediate and its preparation method
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The invention relates to an intermediate of a pentose compound and a preparation method of the intermediate, and particularly relates to intermediates IA and IB of fondaparinux sodium and a preparation method thereof. According to the intermediate and the preparation method disclosed by the invention, substituted benzoyl is taken as a hydroxyl protective group for the intermediate IA, and the IA is used for preparing the intermediate IB of the fondaparinux sodium, wherein the operation is simple, and the productive rate and the yield are both high; moreover, the intermediate is easy to cure and pure in each reaction step, so the intermediate is more suitable for industrial production; meanwhile, the invention also relates to application of the intermediate IB in preparation of the fondaparinux sodium. The intermediates IA and IB are as shown in the specification.
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Paragraph 0088-0090; 0104; 0114
(2018/06/21)
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- the sulphur reaches the liver last of the ten Heavenly Stems sodium and intermediate thereof, and preparation method
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The invention relates to fondaparinux sodium, intermediates thereof and preparation methods in the technical field of chemical preparation, particularly relates to the preparation methods of the fondaparinux sodium and the intermediates of the fondaparinux sodium, comprising the fondaparinux sodium, a disaccharide intermediate of the fondaparinux sodium, a tetrasccharide intermediate of the fondaparinux sodium, a pentasaccharide intermediate of the fondaparinux sodium and the corresponding preparation methods. The structure of the fondaparinux sodium is shown as the chemical compound (1). The invention also relates to the disaccharide intermediate, the tetrasccharide intermediate and the pentasaccharide intermediate which are used for preparing the fondaparinux sodium. The invention designs a novel synthetic route to prepare the fondaparinux sodium. The novel synthetic route has mild reactions, good reaction selectivity, strong controllability and low operation difficulty, and is prone to achievement of industrial production.
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Paragraph 0068; 0103; 0107; 0110
(2017/08/25)
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- PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
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The present invention refers to a fly step compounds of formula ABC5 novel sodium [...] provides manufacturing method: In some embodiments, step for the synthesis intermediates are sodium [...] fly is provided in addition. (by machine translation)
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Paragraph 0124-0126
(2017/02/24)
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- PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
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The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
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Paragraph 0076; 0077
(2015/02/19)
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- PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
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The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthes
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Paragraph 0062; 0063
(2015/02/19)
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- PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
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The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
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Paragraph 0057
(2015/02/19)
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- PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM
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The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthes
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Paragraph 0049
(2015/02/19)
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- PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
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Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.
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Page/Page column 18
(2013/02/28)
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- PROCESS FOR THE SYNTHESIS OF UNPROTECTED PENTASACCHARIDES FROM A PROTECTED PENTASACCHARIDE PRECURSOR
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Procedure for the synthesis of deprotected pentasaccharides from a protected precursor pentasaccharide through a reaction procedure having five stages whereamong is included an N-sulphation of amino groups and a hydrogenolysis of benzyl groups. Through th
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Page/Page column 8-9
(2012/01/03)
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- SYNTHESIS OF HEPARIN FRAGMENTS: A METHYL α-PENTANOSIDE WITH HIGH AFFINITY FOR ANTITHROMBIN III
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The synthesis is described of the methyl α-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin III.It was obtained in a yield much better than that of the previously synthesized pentasaccharide and exhibited the same biological properties.
- Petitou, Maurice,Duchaussoy, Philippe,Lederman, Isidore,Choay, Jean,Jaquinet, Jean-Claude,et al.
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