CYCLIC CONJUGATED ENEDIYNES VIA ELIMINATION OF A THIONOCARBONATE IN A LATENT Z-HEX-3-ENE-1,5-DIYNE UNIT
The common sugar dulcitol is transformed into a hex-1,5-diyne with 3,4-dihydroxyls modified as an acetonide; this serves as a building block for the cyclic ene-diynes and allows mild and efficient introduction of the key ene unit at a late stage in ene-diyne synthesis using the reactive Corey-Winter reagent.
Semmelhack, M. F.,Gallagher, James
p. 4121 - 4124
(2007/10/02)
Design, synthesis, and study of simple monocyclic conjugated enediynes. The 10-membered ring enediyne moiety of the enediyne anticancer antibiotics
Following the discovery of the enediyne anticancer antibiotics, investigations were initiated directed toward the design, synthesis, and study of simple monocyclic conjugated enediynes. In this article the synthesis of the parent 10-membered ring enediyne
Nicolaou,Zuccarello,Riemer,Estevez,Dai
p. 7360 - 7371
(2007/10/02)
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