- Iron-catalyzed synthesis of β-chlorovinyl and α,β-alkynyl ketones from terminal and silylated alkynes with acid chlorides
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A simple efficient method for the iron(III)-catalyzed synthesis of substituted β-chlorovinyl ketones and α,β-alkynyl ketones from terminal and silyl-substituted alkynes with acid chlorides, respectively, is described. This method features easily available
- Gandeepan, Parthasarathy,Parthasarathy, Kanniyappan,Su, Tsu-Hui,Cheng, Chien-Hong
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experimental part
p. 457 - 468
(2012/04/05)
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- Iridium-catalyzed addition of acid chlorides to terminal alkynes
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(Chemical Equation Presented) An iridium N-heterocyclic carbene (NHC) complex, IrCl(cod)(IPr), successfully catalyzed an addition of common aromatic acid chlorides to terminal alkynes to afford (Z)-β-chloro-α,β- unsaturated ketones regio- and stereoselectively. When the NHC ligand (IPr) was changed to a phosphine (RuPhos), the addition occurred with decarbonylation to give the corresponding (Z)-vinyl chlorides. Furthermore, the former reaction using IrCl(cod)(IPr) can be applied to the catalytic synthesis of 2,5-disubstituted furans.
- Iwai, Tomohiro,Fujihara, Tetsuaki,Terao, Jun,Tsuji, Yasushi
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supporting information; experimental part
p. 6668 - 6669
(2009/10/30)
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