cas 115545-59-0, 1-adamantylaspartate | Articles data

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Amino Acids and Peptides. Part 19. Synthesis of β-1-and β-2-Adamantyl Aspartates and their Evaluation for Peptide Synthesis
β-1-and β-2-Adamantyl aspartates have been synthesized and their properties examined.Altough the 1-Ada group is labile to TFA, the 2-Ada group is unaffected during TFA treatment, but easily removable by methanesulphonic acid (MSA) at room temperature within 5 min.Both groups are unaffected by treatment with 55percent piperidine under conditions which easily cleave the fluoren-9-ylmethoxycarbonyl (Fmoc) group from α-amino group.Both groups can suppress aspartimide formation as a side reaction under acidic and basic conditions during the synthesis of aspartyl peptides. β-1-or β-2-Adamantyl aspartates may be applicable to solid-phase peptide synthesis in combination with Fmoc or Boc as an Nα-protecting group, respectively.Some properties of the aspartimide moiety are described.
Okada, Yoshio,Iguchi, Shin
p. 2129 - 2136
(2007/10/02)

Synthesis of β-1 and β-2-Adamantylaspartates and their Evaluation for Peptide Synthesis
β-1 and β-2-Adamantylaspartates, H-Asp(O-1-Ada)-OH and H-Asp(O-2-Ada)-OH respectively, were synthesized and their properties examined, showing possible application in solid-phase peptide synthesis when used in combination with the fluoren-9-ylmethoxycarbonyl (Fmoc) group, as an Nα-protecting group; both these new protecting groups can suppress aspartimide formation as a side reaction under acidic and basic conditions.
Okada, Yoshio,Iguchi, Shin,Kawasaki, Koichi
p. 1532 - 1534
(2007/10/02)

Chemical Properties

Melting Point: 240 °C (decomp)
Boiling Point: 439.8°Cat760mmHg
Flash Point:219.8°C
Density: 1.28g/cm³
Vapor Pressure: 5.8E-09mmHg at 25°C
PKA: 2.19±0.23(Predicted)
PSA: 89.62000
LogP: 2.00070

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115545-59-0

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Chemical Properties

Melting Point: 240 °C (decomp)

Boiling Point: 439.8°Cat760mmHg

Flash Point:219.8°C

Density: 1.28g/cm³

Vapor Pressure: 5.8E-09mmHg at 25°C

PKA: 2.19±0.23(Predicted)

PSA: 89.62000

LogP: 2.00070

Global suppliers and manufacturers of 115545-59-0total 0 suppliers on LookChem

Article Database

115545-59-0

Articles about 115545-59-0Total 2 be found

More Articles about upstream products of 115545-59-0

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Chemical Properties

Melting Point: 240 °C (decomp)

Boiling Point: 439.8°Cat760mmHg

Flash Point:219.8°C

Density: 1.28g/cm3

Vapor Pressure: 5.8E-09mmHg at 25°C

PKA: 2.19±0.23(Predicted)

PSA: 89.62000

LogP: 2.00070

Global suppliers and manufacturers of 115545-59-0total 0 suppliers on LookChem

Density: 1.28g/cm³