Malonic ester amide synthesis: An efficient methodology for synthesis of amides
A general methodology malonic ester amide synthesis has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Copyright
Mahajan, Pankaj S.,Mahajan, Jyoti P.,Mhaske, Santosh B.
p. 2508 - 2516
(2013/07/25)
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