Reduction of Lactams and Thiolactams by Sodium Borohydride: Application in the Synthesis of Some Alkaloids
Lactams 1a-8a and thiolactams 1b-8b,9a,10b-12b and 13 could be reduced to their corresponding amines in 70-98percent yield by using borohydide-tert-butyl alcohol-methanol mixtures under reflux.Even the vinylogous amide 19 underwent reduction to afford dep
Mandal, S. B.,Giri, V. S.,Sabeena, M. S.,Pakrashi, S. C.
p. 4236 - 4241
(2007/10/02)
SODIUM BOROHYDRIDE DESULPHURIZATION OF THIOLACTAMS TO AMINES
Sodium Borohydride desulphurizes a variety of thiolactams (1-8) in t-butanol/methanol mixture under reflux to the respective amines (9-16) in good yield.
Mandal, Sukhendu B.,Giri, Venkatachalam S.,Pakrashi, Satyesh C.
p. 11 - 12
(2007/10/02)
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