Synthesis of bis-pyrrole tetra esters and alcohols as novel mimetics of the anticancer mitomycin
Open-chain bis-Reissert compounds 1 were converted to the corresponding bis-oxazolium intermediates via acid-catalyzed intramolecular cyclization. These oxazolium compounds exist in a variety of tautomeric structures in which the meso-ionic form can be in
Synthesis and Reactions of an Open-Chain bis-Reissert Salt Analog
An open-chain bis-Reissert salt analog 5 has been synthesized and fully chacterized.The reaction of the salt analog with methyl acrylate yields the pyrrole 7 which exists in solution in the azafulvene form 7a.The reaction of the salt analog with dimethylacetylene dicarboxylate (DMAD) affords the bispyrrole 9.
Iyer, Radhakrishnan P.,Ratnam, Rakesh K.,Kulkarni, Subodh P.,Sonaseth, Mariam S.
p. 991 - 997
(2007/10/02)
Synthesis of a Bis-α-amino Acid
A double Strecker reaction has provided a novel route to a bis-α-amino acid.In analogy with the behaviour of open-chain Reissert compounds, 5, a dibenzoyl derivative of bis-aminonitrile (4) undergoes a facile anchimerically-assisted transformation to 2.
Iyer, Radhakrishnan P.,Lawate, Saurabh S.,Sonaseth, Mariam S.
p. 3 - 4
(2007/10/02)
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