A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are now under clinical investigation. However, the ATP-binding sites
Aliagas-Martin, Ignacio,Burdick, Dan,Corson, Laura,Dotson, Jennafer,Drummond, Jason,Fields, Carter,Huang, Oscar W.,Hunsaker, Thomas,Kleinheinz, Tracy,Krueger, Elaine,Liang, Jun,Moffat, John,Phillips, Gail,Pulk, Rebecca,Rawson, Thomas E.,Ultsch, Mark,Walker, Leslie,Wiesmann, Christian,Zhang, Birong,Zhu, Bing-Yan,Cochran, Andrea G.
experimental part
p. 3300 - 3307
(2010/03/24)
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