- Cyclic AMP-specific phosphodiesterase inhibitors
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Novel compounds that are potent and selective inhibitors of PIDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as c
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Page column 18
(2008/06/13)
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- 6-phenyltetrahydro-1,3-oxazin-2-one derivative and pharmaceutical composition containing the same
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A 6-phenyltetrahydro-1,3-oxazin-2-one derivative having the formula (I): wherein, R1is an unsubstituted or substituted C1to C8alkyl group; an unsubstituted or substituted C3to C7cycloalkyl group;, etc
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- Use of 2-phenylmorpholin-5-one derivatives
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A 2-phenylmorpholin-5-one derivative having the formula (I): wherein R1 represents a C1 to C8 alkyl group, a C3 to C7 cycloalkyl group or an indanyl group, R2 represents a C1 to C4 alkyl group, R3 represents a hydrogen atom, a C1 to C5 alkyl group, etc., R4 represents a hydrogen atom, a C1 to C6 alkyl group, etc., R5, R6 represent a hydrogen atom, a C1 to C5 alkyl group, etc.,an optical isomer thereof or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof and a pharmaceutical composition containing the same.The above compound has a strong type IV phosphodiesterase (PDE) inhibitory activity and has bronchodilater and antiinflammatory effects.
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- 5-phenyl-3-pyridazinone derivatives and drug composition containing the same
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A 5-phenyl-3-pyridazinone derivative having the formula (I) wherein R1represents an unsubstituted or substituted C1to C8alkyl group, C3to C7cycloalkyl group, or indanyl group; R2represents
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- Aryl substituted nitrogen heterocyclic antidepressants
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Antidepressant agents having the formula STR1 wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O; and Y comprises a 5-membered heterocyclic ring having one or two nitrogens.
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